Toxic Liver Injury: Some Biochemical Changes in the Liver Caused by Dimethyl-nitrosamine.

The acute liver injury in rat caused by gold nanoparticles

Objective(s):   Gold nanoparticles (GNPs) command a great deal of attention for biomedical applications nowadays. The data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge.  Materials and Methods:  A total of 32 healthy male Wistar rats were randomly divided into 4 including: three GNP-treated and one control group. Groups 1, 2 and 3 receive...

the acute liver injury in rat caused by gold nanoparticles

objective(s):   gold nanoparticles (gnps) command a great deal of attention for biomedical applications nowadays. the data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge.  materials and methods:  a total of 32 healthy male wistar rats were randomly divided into 4 including: three gnp-treated and one control group. groups 1, 2 and 3 receive...

Biochemical and histological changes in rat liver caused by cypermethrin and beta-cyfluthrin.

Cypermethrin and beta-cyfluthrin are two most widely used multipurpose pyrethroids. After determining their oral LD50 (416.98 mg kg-1 and 354.8 mg kg-1 body weight, respectively), we assessed their hepatotoxicity in Wistar rats following acute (0.1 LD50 for 1 day) and sub-acute (0.1 LD50 for 7, 14, 21 or 28 days) poisoning. The assessment was based on hepatic marker enzymes AST, ALT, LDH, ALP, ...

Histological and Biochemical Changes in the Liver of Albino Mice on Exposure to Insecticide, Carbosulfan

Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic e...

Toxic liver injury and carcinogenesis. Methylation of proteins of rat-liver slices by dimethylnitrosamine in vitro.